Schedule and results
| Date | Opponent | Site | Result | Score | Notes |
|---|---|---|---|---|---|
| Sept. 24, 1921 | Samford | Home | W | 34–14 | |
| Oct. 1, 1921 | Spring Hill | Home | W | 27–7 | |
| Oct. 8, 1921 | Marion | Home | W | 55–0 | |
| Oct. 15, 1921 | Bryson | Home | W | 95–0 | |
| Oct. 22, 1921 | Sewanee | Birmingham, AL | L | 0–17 | |
| Oct. 29, 1921 | LSU | New Orleans, LA | T | 7–7 | |
| Nov. 5, 1921 | Vanderbilt | Birmingham, AL | L | 0–14 | |
| Nov. 11, 1921 | Florida | Home | L | 2–9 | |
| Nov. 19, 1921 | Georgia | Atlanta, GA | L | 0–22 † | Conference game |
| Nov. 24, 1921 | Mississippi State | Birmingham, AL | T | 7–7 | Conference game |
| Dec. 3, 1921 | Tulane | Away | W | 14–7 |
† Result disputed between sources. ‡ Result not independently verified.